Game: Organ Donor
Organ Donor is a top-down survival/rescue game. You (a heart) just survived a massive car crash. Collect your fellow organs and get to a hospital! (In order to donate yourself.) CONTROLS: <Arrow keys> for movement. <Right shift> to detach collected organs <Esc> to pause the game. TRANSPLANTS SAVE LIVES: Register your donation decision at http://www.donatelife.gov.au and you could save the lives of up to 10 people and improve the lives of dozens more IRL.
Backwards: One or more aspects of the game works the opposite as would normally be expected: maybe the controller is reversed (left is right, right is left), maybe you win lives every time you die, maybe it scrolls to the left and your character moonwalks.
Bigger Picture: The game touches on a political, environmental or social issue.